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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EN2
All Species:
39.7
Human Site:
T249
Identified Species:
72.78
UniProt:
P19622
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19622
NP_001418.2
333
34211
T249
K
E
D
K
R
P
R
T
A
F
T
A
E
Q
L
Chimpanzee
Pan troglodytes
XP_001146034
399
41238
T315
K
E
D
K
R
P
R
T
A
F
T
A
E
Q
L
Rhesus Macaque
Macaca mulatta
XP_001106130
334
34311
T250
K
E
D
K
R
P
R
T
A
F
T
A
E
Q
L
Dog
Lupus familis
XP_854121
247
25817
T166
K
R
P
R
T
A
F
T
A
E
Q
L
Q
R
L
Cat
Felis silvestris
Mouse
Mus musculus
P09066
324
33799
T240
K
E
D
K
R
P
R
T
A
F
T
A
E
Q
L
Rat
Rattus norvegicus
NP_001102684
323
33670
T239
K
E
D
K
R
P
R
T
A
F
T
A
E
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512614
188
20519
T107
K
R
P
R
T
A
F
T
A
E
Q
L
Q
R
L
Chicken
Gallus gallus
Q05917
288
30431
T204
K
E
D
K
R
P
R
T
A
F
T
A
E
Q
L
Frog
Xenopus laevis
P52729
265
29878
T181
K
E
D
K
R
P
R
T
A
F
T
A
D
Q
L
Zebra Danio
Brachydanio rerio
P31533
261
29466
T180
K
R
P
R
T
A
F
T
A
E
Q
L
Q
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02836
552
59392
T459
N
D
E
K
R
P
R
T
A
F
S
S
E
Q
L
Honey Bee
Apis mellifera
P09076
109
12608
S28
K
R
P
R
T
A
F
S
A
E
Q
L
A
R
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794753
249
28228
L168
T
E
Q
R
R
R
A
L
A
K
E
L
T
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.1
98.1
46.2
N.A.
86.7
86.7
N.A.
48.9
66
57.3
56.1
N.A.
27.5
22.8
N.A.
38.7
Protein Similarity:
100
75.1
99
50.7
N.A.
87.9
88.5
N.A.
52.2
70.5
64.8
63.3
N.A.
37.3
27.3
N.A.
51.3
P-Site Identity:
100
100
100
26.6
N.A.
100
100
N.A.
26.6
100
93.3
26.6
N.A.
66.6
20
N.A.
20
P-Site Similarity:
100
100
100
46.6
N.A.
100
100
N.A.
46.6
100
100
46.6
N.A.
93.3
40
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
31
8
0
100
0
0
54
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
54
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
62
8
0
0
0
0
0
0
31
8
0
54
0
0
% E
% Phe:
0
0
0
0
0
0
31
0
0
62
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
85
0
0
62
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
8
0
0
0
39
0
8
93
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
31
0
0
62
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
31
0
24
62
0
% Q
% Arg:
0
31
0
39
70
8
62
0
0
0
0
0
0
31
0
% R
% Ser:
0
0
0
0
0
0
0
8
0
0
8
8
0
0
8
% S
% Thr:
8
0
0
0
31
0
0
85
0
0
54
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _